ADPKD is the most common inherited cause of kidney disease and the third most common cause of end-stage renal disease (ESRD). Even though it is thought to be primarily a kidney disease, it is truly a systemic disease with significant extra-renal involvement, especially in the liver and intracranial blood vessels. Being an autosomal dominant genetic disease, it impacts families and tends to have significant impact on morbidity, mortality and financial burden that does not only affect the family, but society as well. Because it is a multi-faceted disease, it takes an interdisciplinary team approach to provide the best comprehensive care to the patient and his/her family members. There have been significant advances in our understanding of the pathophysiology of ADPKD and its management. This highly interactive, participatory conference provides clinicians and health care providers with a better understanding and update of the disease state and equips them with the best evidence-based clinical practices. The emphasis will be on practical application of evidence-based medicine and physiological principles to every day clinical care.